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Mobile regions of membrane proteins

Membrane proteins are essential components of all organisms and are critical drug targets. Although we've made major gains in determining the structure of this type of protein, we have few tools that can resolve the portions of membrane proteins that extend past the membrane, that is loop and termini regions. These regions are the portions that allow the protein to sense changes in its environment and are generally the sites where drugs dock. Much of my research is focused on developing methods to resolve the structures of these regions.

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